Our laboratory is centered on understanding the role and regulation of post-translational modifications of the Hsp70 molecular chaperone protein. We are interested in understanding this "Chaperone Code" at both a basic level and in human pathologies that include cancer and neurodegenerative disease.

 

Our group is multidisciplinary, integrating biochemistry, biophysics, structural biology and proteomics. We study these chaperone dynamics in a range of systems including bacteria, budding yeast and in cancer cell lines.