PUBLICATIONS
Truman AW in bold · * corresponding author · † Truman lab graduate student · ‡ Truman lab undergraduate · ¹ equal contribution
For a complete, up-to-date list, see Google Scholar.
2026
1. Woodford MR, Truman AW. Editorial: expanding the chaperone code. Cell Stress Chaperones. 2026 (in press). Link
2. Kalidindi N, Leder A, Mas G, Rebeaud ME, Omkar S, Uthishtran S, Arumugam S, Truman AW, De Los Rios P, Hiller S, Nillegoda NB. A universal tyrosine-based regulatory switch controls J-domain protein activity. Commun Biol. 2026 (in press). Link
3. Barwell T, Gautam D, Nitika, Zheng B, Truman AW, Chakrabarti K. The human DBR1 interactome reveals coupling between intron lariat turnover, pre-mRNA splicing and RNA quality control pathways. Cell Stress Chaperones. 2026:100178. DOI
2025
4. Omkar S, Kline JT, Grissom JH, Sun D, Chi RJ, Bard JAM, Fornelli L, Truman AW*. Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response. Nat Commun. 2025. DOI
5. Bushman Y, Truman AW*. From denaturant to ribosome: rethinking chaperone requirements in cells. Mol Syst Biol. 2025. DOI
6. Mitchem MM, Choi A, Mirikar DA, Deb R, Truman AW*. Dissecting the Cdc37 co-chaperone code: functional roles in chaperone-mediated stress adaptation. J Biol Chem. 2025. DOI
7. Bushman Y, Mirikar D†, Truman AW*. Targeting biomolecular condensates: the rise of engineered chaperones. Cell Chem Biol. 2025;32(3):381–383. DOI
2024
8. Omkar S†, Mitchem MM†, Hoskins JR, Shrader C†, Kline JT, Nitika†, Fornelli L, Wickner S, Truman AW*. Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity. PLoS Genet. 2024;20(12):e1011338. DOI
9. Mirikar D†, Bushman Y†, Truman AW*. Structural transitions modulate the chaperone activities of Grp94. Trends Biochem Sci. 2024. DOI
10. Bourboulia D, Blair LJ, Clark MS, Edkins AL, Hightower LE, Mollapour M, Prahlad V, Repasky EA, Truebano M, Truman AW, Truttmann MC, van Oosten-Hawle P, Woodford MR. Editorial: a new chapter for Cell Stress and Chaperones. Cell Stress Chaperones. 2024. DOI
11. Buchner J, Alasady MJ, Backe SJ, Blagg BS, Carpenter RL, Colombo G, Gelis I, Gewirth DT, Gierasch LM, Houry WA, Johnson JL, Kang BH, Kao AW, LaPointe P, Mattoo S, McClellan AJ, Neckers LM, Prodromou C, Rasola A, Sager RA, Theodoraki MA, Truman AW, Truttmann MC, Zachara NE, Bourboulia D, Mollapour M, Woodford MR. 2nd International Symposium on the Chaperone Code, 2023. Cell Stress Chaperones. 2024. DOI
12. Mitchem MM†, Shrader C†, Abedi E‡, Truman AW*. Novel insights into the post-translational modifications of Ydj1/DNAJA1 co-chaperones. Cell Stress Chaperones. 2024;29:1–9. DOI
2023
13. Omkar S†, Rysbayeva A‡, Truman AW*. Understanding chaperone specificity: evidence for a ‘client code’. Trends Biochem Sci. 2023;48(8):662–664. PubMed
14. Davis JA, Reyes AV, Nitika†, Saha A, Wolfgeher DJ, Xu SL, Truman AW, Li B, Chakrabarti K. Proteomic analysis defines the interactome of telomerase in the protozoan parasite Trypanosoma brucei. Front Cell Dev Biol. 2023;11:1110423. DOI
15. van Oosten-Hawle P, Backe SJ, Ben-Zvi A, Bourboulia D, Brancaccio M, Brodsky J, Clark M, Colombo G, Cox MB, De Los Rios P, Echtenkamp F, Edkins A, Freeman B, Goloubinoff P, Houry W, Johnson J, LaPointe P, Li W, Mezger V, Neckers L, Nillegoda NB, Prahlad V, Reitzel A, Scherz-Shouval R, Sistonen L, Tsai FTF, Woodford MR, Mollapour M, Truman AW*. Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8–9, 2022. Cell Stress Chaperones. 2023. DOI
2022
16. Nitika†, Zheng B, Ruan L, Kline JT, Omkar S†, Sikora J, Torres MT, Wang Y, Takakuwa JE‡, Huguet R, Klemm C, Segarra VA, Winters MJ, Pryciak PM, Thorpe PH, Tatebayashi K, Li R, Fornelli L, Truman AW*. Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by post-translational modifications. PLoS Biol. 2022;20(10):e3001839. DOI
17. Okusha Y, Guerrero-Gimenez ME, Lang BJ, Borges TJ, Stevenson MA, Truman AW, Calderwood SK. MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration. Sci Rep. 2022;12(1):15582.
18. Omkar S, Wani TH, Zheng B, Mitchem MM, Truman AW*. The APE2 exonuclease is a client of the Hsp70–Hsp90 axis in yeast and mammalian cells. Biomolecules. 2022;12(7):864. DOI
19. Omkar S†, Truman AW*. Feeling the heat: how chaperones deal with biomolecular condensates. Trends Biochem Sci. 2022. DOI
20. Knighton LE†, Nitika†, Omkar S†, Truman AW*. The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase. PLoS Genet. 2022;18:e1010079. DOI
21. Millson SH, Truman AW, Piper PW. Hsp90 and phosphorylation of the Slt2(Mpk1) MAP kinase activation loop are essential for catalytic, but not non-catalytic, Slt2-mediated transcription in yeast. Cell Stress Chaperones. 2022. DOI
22. Knighton LE†, Nitika†, Wani TH, Truman AW*. Chemogenomic and bioinformatic profiling of ERdj paralogs underpins their unique roles in cancer. Cell Stress Chaperones. 2022. DOI
23. Goyal S, Segarra VA, Nitika†, Stetcher AM, Truman AW, Reitzel AM, Chi RJ. Vps501, a novel vacuolar SNX-BAR protein, cooperates with the SEA complex to regulate TORC1 signaling. Traffic. 2022. DOI
2021
24. van Oosten-Hawle P, Bergink S, Blagg B, Brodsky J, Edkins A, Freeman B, Genest O, Hendershot L, Kampinga H, Johnson J, et al., Truman AW*. First Virtual International Congress on Cellular and Organismal Stress Responses, November 5–6, 2020. Cell Stress Chaperones. 2021;26:289–295. DOI
25. Truman AW*, Bourboulia D*, Mollapour M*. Decrypting the chaperone code. J Biol Chem. 2021;296:100293. DOI
26. Truman AW*. Dealing with difficult clients via personalized chaperone inhibitors. J Biol Chem. 2021;296:100211. DOI
2020
27. Nitika†, Blackman JS‡, Knighton LE†, Takakuwa JE‡, Calderwood SK, Truman AW*. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020;10:13831. DOI
28. Nitika†, Porter CM, Truman AW*, Truttmann MC*. Post-translational modifications of Hsp70 family proteins: expanding the chaperone code. J Biol Chem. 2020;295:10689–10708. DOI
29. Jeffries AM, Nitika†, Truman AW, Marriott I. The intracellular DNA sensors cGAS and IFI16 do not mediate effective antiviral immune responses to HSV-1 in human microglial cells. J Neurovirol. 2020. DOI
30. Weissman Z, Pinsky M, Wolfgeher DJ, Kron SJ, Truman AW*, Kornitzer D*. Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis. Biochim Biophys Acta Proteins Proteom. 2020;1868:140135. PDF
31. Rigo MM, Borges TJ, Lang BJ, Murshid A, Nitika†, Wolfgeher D, Calderwood SK, Truman AW, Bonorino C. Host expression system modulates recombinant Hsp70 activity through post-translational modifications. FEBS J. 2020. DOI
2019
32. Xu L, Nitika†, Hasin N, Cuskelly DD, Wolfgeher D, Doyle S, Moynagh P, Perrett S, Jones GW, Truman AW*. Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress. Sci Rep. 2019;9:16260. DOI Recommended by Faculty of 1000.
33. Takakuwa JE‡, Nitika†, Knighton LE†, Truman AW*. Oligomerization of Hsp70: current perspectives on regulation and function. Front Mol Biosci. 2019;6:81. DOI
34. Ricco N, Flor A, Wolfgeher D, Efimova EV, Ramamurthy A, Appelbe OK, Brinkman J, Truman AW, Spiotto MT, Kron SJ. Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Mol Oncol. 2019;13:1927–1943. PDF
35. Lotz SK‡, Knighton LE†, Nitika†, Jones GW, Truman AW*. Not quite the SSAme: unique roles for the yeast cytosolic Hsp70s. Curr Genet. 2019;65:1127–1134. DOI
36. Knighton LE†, Truman AW*. Role of the molecular chaperones Hsp70 and Hsp90 in the DNA damage response. In: Heat Shock Proteins in Signaling Pathways. Heat Shock Proteins, vol 17. Springer; 2019:345–358. DOI
37. Knighton LE†, Saa LP‡, Reitzel AM, Truman AW*. Analyzing the functionality of non-native Hsp70 proteins in Saccharomyces cerevisiae. Bio Protoc. 2019;9:e3389. DOI
38. Knighton LE†, Nitika†, Wolfgeher D, Reitzel AM, Truman AW*. Dataset of Nematostella vectensis Hsp70 isoform interactomes upon heat shock. Data Brief. 2019;27:104580. Link
39. Knighton LE†, Nitika†, Waller SJ†, Strom O, Wolfgeher D, Reitzel AM, Truman AW*. Dynamic remodeling of the interactomes of Nematostella vectensis Hsp70 isoforms under heat shock. J Proteomics. 2019;206:103416. Link
40. Knighton LE†, Delgado LE‡, Truman AW*. Novel insights into molecular chaperone regulation of ribonucleotide reductase. Curr Genet. 2019;65:477–482. DOI
2018
41. Waller SJ†, Knighton LE†, Crabtree LM, Perkins AL, Reitzel AM, Truman AW*. Characterizing functional differences in sea anemone Hsp70 isoforms using budding yeast. Cell Stress Chaperones. 2018;23:933–941. PMC
42. Sluder IT, Nitika†, Knighton LE†, Truman AW*. The Hsp70 co-chaperone Ydj1/HDJ2 regulates ribonucleotide reductase activity. PLoS Genet. 2018;14:e1007462. DOI
43. Nitika†, Truman AW*. Endogenous epitope tagging of heat shock protein 70 isoform Hsc70 using CRISPR/Cas9. Cell Stress Chaperones. 2018;23:347–355.
2017
44. Nitika†, Truman AW*. Cracking the chaperone code: cellular roles for Hsp70 phosphorylation. Trends Biochem Sci. 2017;42:932–935. PMC
45. Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M. Phosphorylation and ubiquitination regulate protein phosphatase 5 activity and its prosurvival role in kidney cancer. Cell Rep. 2017;21:1883–1895.
2016
46. Woodford MR, Truman AW¹, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, Trepel JB, Landas S, Prodromou C, Shapiro O, Stetler-Stevenson WG, Bourboulia D, Neckers L, Bratslavsky G, Mollapour M. Mps1-mediated phosphorylation of Hsp90 confers renal cell carcinoma sensitivity and selectivity to Hsp90 inhibitors. Cell Rep. 2016;14:872–884.
2015
47. Wolfgeher D, Dunn DM, Woodford MR, Bourboulia D, Bratslavsky G, Mollapour M, Kron SJ, Truman AW*. The dynamic interactome of human Aha1 upon Y223 phosphorylation. Data Brief. 2015;5:752–755.
48. Truman AW, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum SL, Clotet J, Kron SJ. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics. 2015;112:285–300.
49. Truman AW, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum SL, Clotet J, Kron SJ. The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage. Data Brief. 2015;2:12–15.
50. Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M. c-Abl mediated tyrosine phosphorylation of Aha1 activates its co-chaperone function in cancer cells. Cell Rep. 2015;12:1006–1018.
2014
51. Millson S, van Oosten-Hawle P, Alkuriji MA, Truman AW, Siderius M, Piper PW. Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1). Cell Stress Chaperones. 2014;19:695–703.
2013
52. Jimenez J, Truman AW, Menoyo S, Kron SJ, Clotet J. The yin and yang of cyclin control by nutrients. Cell Cycle. 2013;12:865–866.
53. Balogun FO, Truman AW, Kron SJ. DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast. DNA Repair (Amst). 2013;12:751–760.
2012
54. Truman AW, Kristjansdottir K, Wolfgeher D, Hasin N, Polier S, Zhang H, Perrett S, Prodromou C, Jones GW, Kron SJ. CDK-dependent Hsp70 phosphorylation controls G1 cyclin abundance and cell-cycle progression. Cell. 2012;151:1308–1318. Recommended by Faculty of 1000.
55. Truman AW, Kitazono AA, Fitzgerald JN, Kron SJ. Cell cycle: regulation by cyclins. In: Encyclopedia of Life Sciences (eLS). Wiley; 2012. DOI
2011
56. Mollapour M, Tsutsumi S, Truman AW, Xu W, Vaughan CK, Beebe K, Konstantinova A, Vourganti S, Panaretou B, Piper PW, Trepel JB, Prodromou C, Pearl LH, Neckers L. Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Mol Cell. 2011;41:672–681.
2010
57. Rossetto D, Truman AW, Kron SJ, Côté J. Epigenetic modifications in double-strand break DNA damage signaling and repair. Clin Cancer Res. 2010;16:4543–4552.
58. Kim KY, Truman AW, Caesar S, Schlenstedt G, Levin DE. Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator. Mol Biol Cell. 2010;21:1609–1619.
2009
59. Truman AW, Kim KY, Levin DE. Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation. Mol Cell Biol. 2009;29:6449–6461.
2008
60. Vaughan CK, Mollapour M, Smith JR, Truman AW, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell. 2008;31:886–895.
61. Kim KY, Truman AW, Levin DE. Yeast Mpk1 mitogen-activated protein kinase activates transcription through Swi4/Swi6 by a noncatalytic mechanism that requires upstream signal. Mol Cell Biol. 2008;28:2579–2589.
2007
62. Truman AW, Millson SH, Nuttall JM, Mollapour M, Prodromou C, Piper PW. In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity. Eukaryot Cell. 2007;6:744–752.
63. Millson SH, Truman AW, Racz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Söti C, Piper PW. Expressed as the sole Hsp90 of yeast, the α and β isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90β generates sensitivity to the Hsp90 inhibitor radicicol. FEBS J. 2007;274:4453–4463.
2006
64. Truman AW, Millson SH, Nuttall JM, King V, Mollapour M, Prodromou C, Pearl LH, Piper PW. Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase. Eukaryot Cell. 2006;5:1914–1924.
65. Piper PW, Truman AW, Millson SH, Nuttall J. Hsp90 chaperone control over transcriptional regulation by the yeast Slt2(Mpk1)p and human ERK5 mitogen-activated protein kinases (MAPKs). Biochem Soc Trans. 2006;34:783–785.
2005
66. Millson SH, Truman AW, King V, Prodromou C, Pearl LH, Piper PW. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryot Cell. 2005;4:849–860.
2004
67. Millson SH, Truman AW, Wolfram F, King V, Panaretou B, Prodromou C, Pearl LH, Piper PW. Investigating the protein–protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach. Cell Stress Chaperones. 2004;9:359–368.
2003
68. Piper PW, Panaretou B, Millson SH, Truman AW, Mollapour M, Pearl LH, Prodromou C. Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targeting drugs with heterologous expression of the human Hsp90β, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. Gene. 2003;302:165–170.
69. Millson SH, Truman AW, Piper PW. Vectors for N- or C-terminal positioning of the yeast Gal4p DNA binding or activator domains. Biotechniques. 2003;35:60–64.
